Efficient Closed Pattern Mining in the Presence of Tough Block Constraints

In recent years, various constrained frequent pattern mining problem formulations and associated algorithms have been developed that enable the user to specify various itemsetbased constraints that better capture the underlying application requirements and characteristics. In this paper we introduce a new class of block constraints that determine the significance of an itemset pattern by considering the dense block that is formed by the pattern's items and its associated set of transactions. Block constraints provide a natural framework by which a number of important problems can be specified and make it possible to solve numerous problems on binary and real-valued datasets. However, developing computationally e#cient algorithms to find these block constraints poses a number of challenges as unlike the di#erent itemset-based constraints studied earlier, these block constraints are tough as they are neither anti-monotone, monotone, nor convertible. To overcome this problem, we introduce a new class of pruning methods that can be used to significantly reduce the overall search space and make it possible to develop computationally e#cient block constraint mining algorithms. We present an algorithm called CBMiner that takes advantage of these pruning methods to develop an algorithm for finding the closed itemsets that satisfy the block constraints. Our extensive performance study shows that CBMiner generates more concise result set and can be order(s) of magnitude faster than the traditional frequent closed itemset mining algorithms

Phytochemical evaluation and anti-psoriatic activity of the ethanolic extract of the leaves of Momordica charantia

Psoriasis is a chronic, inflammatory, multi factorial disease. Topical chemical agents are used to treat psoriasis, despite their lower effectiveness or ineffective effects. Herbal medicine can be one of the alternative treatment methods. Momordica charantia is traditionally used to treat skin diseases, especially psoriasis. The main phytochemicals responsible for antipsoriatic activity is stigmasterol, taraxerol, lofenol, phenylpropanoids and squalene. The alcoholic soxhlation method was used to obtain the percentage phytochemical yield of 13.36% w/w, which was used for antipsoriatic activity using a mouse tail model of psoriasis. The extract produced significant differentiation of the epidermis as evidenced by the degree of orthokeratosis 70.18 ± 2.64% compared to the negative control 17.30 ± 4.09%. This was equivalent to the effect of the standard positive control, tazarotene gel (0.1%), which showed a degree of orthokeratosis of 90.03 ± 2.00%. The extract showed an overall antipsoriatic activity of 63.94%

Synthesis, spectral characterization, anti-bacterial, cytotoxic evaluation and docking studies of new urea and thiourea derivatives

Isoniazid is one of the main API’s used in the combination treatment of tuberculosis recommended by the WHO. Urea and its derivatives are an important class of heterocyclic compounds that possess a wide range of therapeutic and pharmacological properties, while thiourea is an organosulphur compound in that it resembles urea except that the atom oxygen has been replaced by a Sulphur atom, but the properties of urea and thiourea are significantly different. The current work concerns the synthesis of a new class of urea and thiourea derivatives of isoniazid with various isocyanates and isothiocyanates in the presence of trimethylamine. The IR and NMR spectral data were performed for the urea and thiourea derivatives of the compounds [(3c & 3f) & (3d & 3e)], respectively. Molecular docking studies of the compounds (3a-h) revealed the binding mode involved in the active site of DNA gyrase. The synthesized urea and thiourea derivatives of isoniazid with various isocyanates and isothiocyanates were tested for their antibacterial activity against gram-positive and gram-negative bacteria using the “disc diffusion method”. Of all compounds tested, the urea derivatives (3a &3d), the thiourea derivatives (3e & 3g) showed more potent activity than the other compounds. The MTT assay revealed concentration dependent cytotoxic effects over a concentration range 25-200 µg/mL

Polycystic ovarian syndrome (PCOS): Approach to traditional systems, natural and bio-chemical compounds for its management

521-527Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder which is characterized by chronic anovulation. Irregular periods, hirsutism, weight gain are the other signs of PCOS. The prevalence of PCOS worldwide is between 6% and 26% while in India it was 3.7% to 22.5%. PCOS is the most prevailing female endocrine disorder and the preeminent cause of infertility. Risk factors that contribute to the development of PCOS include genetics, neuroendocrine system, sedentary lifestyle, diet, and obesity. Modern medicine has found many ways to heal. Synthetic drugs such as metformin and oral contraceptive pills were available in the market, but because of their side effects, people depend on traditional and herbal medicines. This review provides a detailed approach to different types of traditional and natural systems for the treatment and management of PCOS. Different approaches to managing PCOS include the traditional system of drugs, herbal remedies, herbs, and Phyto-ingredients that have proven their potential in treating PCOS. Traditional medicine includes Unani, Ayurveda, Siddha, naturopathy, yoga, and homeopathy. In addition to treatment, yoga also has potential in treating PCOS

Retrofitting of heat exchanger networks involving streams with variable heat capacity: Application of single and multi-objective optimization

10.1016/j.applthermaleng.2014.09.067Applied Thermal Engineering75677-68

Study of surgical management of proximal tibial fractures using anatomical proximal tibia locking compression plate

Background: Treatment of these proximal tibia fractures using minimally invasive percutaneous plate osteosynthesis (MIPPO) techniques may minimize soft tissue injuries and damage to vascular integrity of fracture fragments. Methods: This study was a hospital based prospective study centred in department of orthopaedics at GSL Medical College Rajahmundry, from December 2017 to May 2019 in which 20 patients with proximal tibia fractures. These patients were treated with locking compression plate (LCP). Results: The assessment of clinical outcome was made according to Rasmussen’s functional grading system. End results showed excellent outcome and out of 20 patients, 19 Patients (85%) showed radiological UNION Conclusion: Surgical management of proximal tibial fractures will give excellent anatomical reduction and rigid fixation to restore articular congruity, help to facilitate early mobilization and reducing post-traumatic osteoarthritis and hence to achieve optimal knee function. LCP remains a good choice in comminuted or more severe patterns of fractures

Earlybird: Real-Time Search at Twitter

Abstract — The web today is increasingly characterized by social and real-time signals, which we believe represent two frontiers in information retrieval. In this paper, we present Earlybird, the core retrieval engine that powers Twitter’s realtime search service. Although Earlybird builds and maintains inverted indexes like nearly all modern retrieval engines, its index structures differ from those built to support traditional web search. We describe these differences and present the rationale behind our design. A key requirement of real-time search is the ability to ingest content rapidly and make it searchable immediately, while concurrently supporting low-latency, highthroughput query evaluation. These demands are met with a single-writer, multiple-reader concurrency model and the targeted use of memory barriers. Earlybird represents a point in the design space of real-time search engines that has worked well for Twitter’s needs. By sharing our experiences, we hope to spur additional interest and innovation in this exciting space. I